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The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency

Received: 19 March 2022     Accepted: 9 April 2022     Published: 28 April 2022
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Abstract

The paper presents a comparative analysis of data on the effect of moderate and acute hypoxia on the functional state of systems at various levels of organization - molecular (amide groups of brain proteins), cellular (background electrical activity of neurons), systemic (electroencephalogram - EEG, electrocardiogram (ECG) and organismic (integrative signal of the body). Changes in electrographic parameters have an adaptive meaning for the body and are of a phase nature: in moderate hypoxia (4500-5000 m) the indicators are activated, and at acute hypoxia (7500 - 8000 m) - are depressed. 15-30 minutes after exposure to hypoxia at normal atmospheric pressure, the values of almost all indicators are back to normal. It is shown, that a prolonged aftereffect of acute hypoxia is observed at the organism molecular level. Under oxygen deficiency, the number of amide groups of brain proteins increases. After the hypoxic factor, this violation persists for a day. The data of the influence of hypoxia on animals, lead to the conclusion, that the functional systems of different levels of organization react ambiguously to the impact of increasing oxygen deficiency. However, in the dynamics of hypoxia in the values of the integrative signal recorded by a non-invasive method from the body surface, phase changes are not observed, on the contrary, the shifts are unidirectional. Certain deviations of the indicators of the integrative signal in the phase of moderate hypoxia increase during acute hypoxia and continue for several hours. We conclude that the remote "Bioscope" signal being integral in nature, is not the sum of individual electrographic indicators of various functional systems and has a high sensitivity and specificity to the change of physiological state of animal.

Published in American Journal of BioScience (Volume 10, Issue 2)
DOI 10.11648/j.ajbio.20221002.18
Page(s) 89-93
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Oxygen Deficiency, Neuronal Activity, Electroencephalogram (EEG), Electrocardiogram (ECG), Integrative Field, Brain Proteins

References
[1] Laciga P., Koller E. (1976). Respiratory, circulatory and ECG changes during acute exposure to high altitude. J. Appl Physiol, 41 (2): 159-67. doi: 10.1152/jappl.1976.41.2.159.
[2] Georges T., Le Blanc C., Ferreol S., Menu P., Dauty M. and Fouasson-Chailloux A. (2021). Effects of Altitude on Chronic Obstructive Pulmonary Disease Patients: Risks and Care. Life, 11, 798. https:// doi.org/10.3390/life11080798
[3] Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang and Shaw-Jenq Tsai. (2020). Pathophysiological implications of hypoxia in human diseases. Journal of Biomedical Science, 27, (63). https://doi.org/10.1186/s12929-020-00658-7
[4] Fine L., Norman J. (2008) Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Progression of renal disease. 74 (7): 867-872. doi: 10.1038/ki.2008.350.
[5] Naeije R. (2010). Physiological adaptation of the cardiovascular system to high altitude. Progress in Cardiovascular Diseases, 52 (6): 456-66. doi: 10.1016/j.pcad.2010.03.004.
[6] Vaccari A, Brotman S, Cimino, Timiras P. S. (1978). Adaptive changes induced by high altitude in the development of brain monoamine enzymes. Neurochem. Res. (3): 295-311. DOI: 10.1007/BF00965576.
[7] Prabhakar N. R. (2003). Oxygen Sensing | Responses and Adaption to Hypoxia, e-Book: 576. https://www.taylorfrancis.com › books › oxygen-sensin...
[8] Yajima D, Motani H, Hayakawa M, Sato Y, Sato K, Iwase H. (2009). The relationship between cell membrane damage and lipid peroxidation under the condition of hypoxia-reoxygenation: analysis of the mechanism using antioxidants and electron transport inhibitors. Cell Biochem Funct. (6): 338-43. doi: 10.1002/cbf.1578.
[9] Sargsyan R. S., Gevorkyan A. S, Karamyan G. G., VardanyanV. T., Manukyan A. V., Nikogosyan A. H. (2010). Bioscope: New Sensor for Remote Evaluation of The Physiological State of Biological Systems. Part of the NATO Science for Peace and Security Series B: Physics and Biophysics, book series (NAPSB) 07 Physical Properties of Nanosystems: 299-309. https://link.springer.com/chapter/10.1007/978-94-007-0044-4_24
[10] Sargsyan R. Sh., Karamyan G. G., Avagyan M. N. (2010). Noninvasive Assessment of Physiologic State of Living Systems, The Journal of Alternative and Complementary Medicine, 16 (11) Original Articles. https://doi.org/10.1089/acm.2010.0108
[11] Sargsyan R. Sh., Karamyan G. G., Gevorkyan A. S., Manukyan A. M., Va rdanyan V. T., Nikoghosyan A. G., and Sargsyan V. R. (2011). Nonlocal Interactions between Two Spatially Divided Light Fluxes. AIP Conference Proceedings 1327, 465. https://doi.org/10.1063/1.3567475
[12] Draayer J. P., Grigoryan H. R., Sargsyan R. Sh., Ter-Grigoryan S. A. (2007) Systems and Methods for Investigation of Living Systems, Bioscope: a novel apparatus for the investigation US Patent Application / 0149866 A1.
[13] Avshalumov A. Sh., Sudakov K. V., Filaretov G. F. (2006). A new information technology for system diagnosis of functional activity of organs of the human body. Biomedical Engineering, 40 (3): 120-24. doi: 10.1007/s10527-006-0058-y.
[14] Adamyan N., Karapetyan M., Sargsyan R., Ayrapetyan T. (2018). Change in the integrative indicators of the body or oxygen insufficiency under effects of nembutal and urethane. Biol. J. of Armenia. 1 (70): 85-89. http://www.ysu.am/files/2-1541659698-.pdf
[15] Silakova A. I., Trubin G. P., Yavlikova A. I. (1962). Micromethod for the determination of ammonia and glutamine in tissue trichloroacetic extracts. Medical questions. Chemistry, 8 (5): 538-544.
[16] EuroScience supports Directive 2010/63/EU on the protection of animals used for scientific purposes ". (2015). EuroScience. Retrieved 2016.
[17] Karapetian M. A, Adamian N. Yu. (2014). Effects of stimulating some dorsohypothalamic nuclei on the firing activity of bulbar respiratory neurons during hypoxia. Aviakosm. Ekolog. Med., 48 (2): 35-42. PMID: 25087410, https://pubmed.ncbi.nlm.nih.gov/25087410/.
[18] Lovering A. T., Fraigne J. J., Dunin-Barkowski W. L., Vidruk E. H., Orem J. M. (2006). Medullary Respiratory Neural Activity During Hypoxia in NREM and REM Sleep in the Cat. J Neurophysiol., 95: 803– 810, https://journals.physiology.org › doi›pdf. doi: 10.1152/jn.00615.2005.
[19] Egerer E., Siemonsen S., Erbguth F. (2018). Acute diseases of the brain and heart: A reciprocal culprit-victim relationship. Med Klin Intensivmed Notfmed, 113 (6): 456-463. doi: 10.1007/s00063-018-0465-3.
[20] Nolan P. C., Waldrop T. G. (1993). In vivo and in vitro responses of neurons in the ventrolateral medulla to hypoxia. Brain Res; 630: 101–114. doi: 10.1016/0006-8993(93)90648-7.
[21] Kraaier V., Van Huffelen G. A., Wieneke G. H. (1988). Quantitative EEG changes due to hypobaric hypoxia in normal subjects. Electroencephalography and Clinical Neurophysiology, 69, (4): 303-312. https://doi.org/10.1016/0013-4694(88)90002-8
[22] Papadelis C., Kourtidou-Papadeli C., Bamidis P. D., Maglaveras N., Pappas, K. (2007). The effect of hypobaric hypoxia on multichannel EEG signal complexity. Clinical Neurophysiology, 118, (1): 31-52 doi: 10.1016/j.clinph.2006.09.008.
[23] Carta A., Bitos K., Furian M., Mademilov M., Sheraliev U., Marazhapov N. H., Lichtblau M., Schneider S., Sooronbaev T., Bloch K. E., Ulrich S. (2021). ECG changes at rest and during exercise in lowlanders with COPD travelling to 3100 m. Int J Cardiol. (324): 173-179. doi: 10.1016/j.ijcard.2020.09.055.
[24] Adav S. S., Sze S. K. (2020). Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders. Aging and disease, 11 (2): 341-364. doi: 10.14336/AD.2019.0604.
Cite This Article
  • APA Style

    Marietta Karapetyan, Nonna Adamyan, Susanna Sahakyan. (2022). The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency. American Journal of BioScience, 10(2), 89-93. https://doi.org/10.11648/j.ajbio.20221002.18

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    ACS Style

    Marietta Karapetyan; Nonna Adamyan; Susanna Sahakyan. The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency. Am. J. BioScience 2022, 10(2), 89-93. doi: 10.11648/j.ajbio.20221002.18

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    AMA Style

    Marietta Karapetyan, Nonna Adamyan, Susanna Sahakyan. The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency. Am J BioScience. 2022;10(2):89-93. doi: 10.11648/j.ajbio.20221002.18

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  • @article{10.11648/j.ajbio.20221002.18,
      author = {Marietta Karapetyan and Nonna Adamyan and Susanna Sahakyan},
      title = {The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency},
      journal = {American Journal of BioScience},
      volume = {10},
      number = {2},
      pages = {89-93},
      doi = {10.11648/j.ajbio.20221002.18},
      url = {https://doi.org/10.11648/j.ajbio.20221002.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20221002.18},
      abstract = {The paper presents a comparative analysis of data on the effect of moderate and acute hypoxia on the functional state of systems at various levels of organization - molecular (amide groups of brain proteins), cellular (background electrical activity of neurons), systemic (electroencephalogram - EEG, electrocardiogram (ECG) and organismic (integrative signal of the body). Changes in electrographic parameters have an adaptive meaning for the body and are of a phase nature: in moderate hypoxia (4500-5000 m) the indicators are activated, and at acute hypoxia (7500 - 8000 m) - are depressed. 15-30 minutes after exposure to hypoxia at normal atmospheric pressure, the values of almost all indicators are back to normal. It is shown, that a prolonged aftereffect of acute hypoxia is observed at the organism molecular level. Under oxygen deficiency, the number of amide groups of brain proteins increases. After the hypoxic factor, this violation persists for a day. The data of the influence of hypoxia on animals, lead to the conclusion, that the functional systems of different levels of organization react ambiguously to the impact of increasing oxygen deficiency. However, in the dynamics of hypoxia in the values of the integrative signal recorded by a non-invasive method from the body surface, phase changes are not observed, on the contrary, the shifts are unidirectional. Certain deviations of the indicators of the integrative signal in the phase of moderate hypoxia increase during acute hypoxia and continue for several hours. We conclude that the remote "Bioscope" signal being integral in nature, is not the sum of individual electrographic indicators of various functional systems and has a high sensitivity and specificity to the change of physiological state of animal.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency
    AU  - Marietta Karapetyan
    AU  - Nonna Adamyan
    AU  - Susanna Sahakyan
    Y1  - 2022/04/28
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajbio.20221002.18
    DO  - 10.11648/j.ajbio.20221002.18
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
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    EP  - 93
    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.20221002.18
    AB  - The paper presents a comparative analysis of data on the effect of moderate and acute hypoxia on the functional state of systems at various levels of organization - molecular (amide groups of brain proteins), cellular (background electrical activity of neurons), systemic (electroencephalogram - EEG, electrocardiogram (ECG) and organismic (integrative signal of the body). Changes in electrographic parameters have an adaptive meaning for the body and are of a phase nature: in moderate hypoxia (4500-5000 m) the indicators are activated, and at acute hypoxia (7500 - 8000 m) - are depressed. 15-30 minutes after exposure to hypoxia at normal atmospheric pressure, the values of almost all indicators are back to normal. It is shown, that a prolonged aftereffect of acute hypoxia is observed at the organism molecular level. Under oxygen deficiency, the number of amide groups of brain proteins increases. After the hypoxic factor, this violation persists for a day. The data of the influence of hypoxia on animals, lead to the conclusion, that the functional systems of different levels of organization react ambiguously to the impact of increasing oxygen deficiency. However, in the dynamics of hypoxia in the values of the integrative signal recorded by a non-invasive method from the body surface, phase changes are not observed, on the contrary, the shifts are unidirectional. Certain deviations of the indicators of the integrative signal in the phase of moderate hypoxia increase during acute hypoxia and continue for several hours. We conclude that the remote "Bioscope" signal being integral in nature, is not the sum of individual electrographic indicators of various functional systems and has a high sensitivity and specificity to the change of physiological state of animal.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Department of Human and Animal Physiology, Faculty of Biology, Yerevan State University, Yerevan, Armenia

  • Department of Human and Animal Physiology, Faculty of Biology, Yerevan State University, Yerevan, Armenia

  • Department of Human and Animal Physiology, Faculty of Biology, Yerevan State University, Yerevan, Armenia

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